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The loss of LPCAT3 or ACSL4 depletes the substrates for lipid peroxidation and increases ferroptosis resistance [47]

doi: 10.1007/s00005-012-0162-5 74 BlancoILaraBde SerresF

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In reactive astrocytes, MAO-B activity is notably elevated, leading to increased production of H 2 O 2 , while NADPH oxidase 2 is frequently upregulated, further amplifying ROS generation [359, 363]