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Intestinal barrier dysfunction (leaky gut) permits inappropriate passage of food proteins, microbial components, and environmental toxins into circulation, potentially triggering immune responses that cross-react with body tissues

Here, we report that in givosiran-treated patients, the drug can severely impair homocysteine degradation leading to excessively high plasma homocysteine levels

doi: 10.3390/molecules29163941 255

Once inside, cystine is converted into cysteine, which is essential for the synthesis of glutathione

It participates in the conjugation of toxins, particularly in the liver

71 LuoZ.HaradaT.LondonS.GajdusekC.MaybergM