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Although the precise prevalence of painful peripheral neuropathy in cirrhosis remains elusive, research has revealed that 15% of cirrhotic patients manifest neuropathic symptoms such as numbness and paraesthesia ( 10.3 Treatment and adjunctive management General principles include addressing comorbid symptoms (such as sleep, mood, memory, fatigue, and psychiatric disorders), emphasizing self-management tools, and employing multimodal therapies that combine several non-pharmacologic strategies

Furthermore, melatonin-induced changes in glycosaminoglycan production may impact the TM, which regulates IOP, potentially influencing the pathophysiology of POAG (81)

10.1002/bmb.2005.494033032451 17 BalesB

5.6 Cerebrovascular diseases Interestingly, several studies have reported promising effects of pepper family derivatives in case of ameliorating risk factors for cerebrovascular diseases and reversing the outcomes such as neural damage