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[] METTL4 is localized to mitochondria, preferentially methylates promoter regions of mtDNA, and disrupts assembly of the transcription initiation complex, leading to transcriptional stalling, impaired electron transport chain (ETC) genes expression, mitochondrial respiratory deficiency, and ultimately HF

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It is therefore likely that these partially redundant AMPs in the CNS could compensate for each others weaknesses, yet still co-operate when encountering a mutually specific pathogen

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Each IVF experiment was repeated three times, with 45 oocytes used per replicate