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Upon receiving electrons from POR, with NADPH serving as the electron donor, downstream electron acceptors such as cytochrome b5 type A and cytochrome P450 undergo reduction, which could subsequently induce lipid peroxidation through reducing ferric iron or removing methylene hydrogen from PUFAs (38, 39)

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Whereas statins (214216), and niacin (217) in addition to the HO-1 induction mentioned above, include inhibition of basolateral transport of unconjugated bilirubin, the latter may be more important

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