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The most accepted hypothesis suggests that chronic inflammatory reaction at the site of injection provides a trigger for subsequent malignant transformation (Hartmann et al., 2015)

These cells have a defect in OXPHOS and rely on oxidative glutamine-glutamate-alpha-ketoglutarate metabolism for survival (Figure 2)

The commenters request CMS to clarify how the current policy and the cost-sharing calculations for diagnostic radiopharmaceuticals meets the intent of the statute

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