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This process limits the uptake of DOX and promotes the emergence of drug resistance 44

This is crucial for understanding the proteoform concept (Smith et al., 2013) highlighting the idea that the complexity of biological systems is not solely dictated by their genome size, but rather by the vast and functionally diverse proteome, consisting of a multitude of unique proteoforms derived from a relatively small number of genes (Schluter et al., 2009)

2) then, surrogates for pathogen reduction that can be continuously measured were identified

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