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In experimental autoimmune encephalomyelitis model of MS, AMPK signaling is required for oligodendrocyte function [228]

Unlike apoptosis, its execution is independent of caspases and is instead driven by receptor-interacting protein kinase 1 (RIPK1) and receptor-interacting protein kinase 3 (RIPK3), with mixed lineage kinase domain-like protein (MLKL) acting as the executioner by oligomerizing and forming pores in the plasma membrane, leading to its rupture (41)

In pregnant rabbits given daily subcutaneous doses of zoledronic acid of 0.01, 0.03, or 0.1 mg/kg during gestation, no adverse fetal effects were observed up to 0.1 mg/kg/day (0.4 times the human 5 mg intravenous dose, based on body surface area, mg/m2)

Hullings, Isis Trujillo-Gonzalez, Kevin C

When the staining workflow was resumed the following day, cells were permeabilized with BD Perm/Wash buffer for 15 min prior to being stained for 30 min at RT with anti-IL-17A (BioLegend, clone TC11-18H10.1, Cat