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Lipopolysaccharide-induced testicular dysfunction and epididymitis in mice: a critical role of tumor necrosis factor alpha

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Upon bacterial infection, WRS is secreted by the monocytes, and directly binds to macrophages via a toll-like receptor 4 (TLR4)-myeloid differentiation factor 2 (MD2) complex, inducing phagocytosis and chemokine production ( in vitro and in vivo (Lee et al., 2019)

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The cell lines used were obtained from Shanghai Cell Bank of the Chinese Academy of Sciences and were used in accordance with the guidelines provided by the supplier

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