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Beyond its cytoplasmic role, ATOX1 can translocate to the nucleus and function as a copper-dependent transcription factor, potentially regulating pathways such as HIF-1 signaling [93] (Figure 4)

Hydroxocobalamin is well retained, which is why it is used for injections, while methylcobalamin is a coenzyme form the body uses directly and is common in oral tablets

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A well-hydrated skin barrier is more receptive to active ingredients and can better support the cellular processes GHK-Cu initiates