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SKU: 39324653082
Price: 29.44 USD
Availability: InStock
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High-Frequency, Precise Modification of the Tomato Genome

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Up to now, powerful genetic tools allowed clarification of the significance, dispensability and potential of cystine transporters for ferroptotic cell death in PDAC and breast cancer ( via xCT ( A high extracellular glutamate concentration was one of the first xCT inhibitors described but a few years later, erastin (standing for eradicator of RAS and small T antigen-expressing cells) was identified by Stockwell's group in RAS-mutated cancer cell lines as inhibitor of xCT transport ( in vitro studies as efficient inducer of ferroptosis in many different cancer types, including breast, PDAC, lymphoma, renal, brain and ovarian cancers (50, 51) and sorafenib (52)

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This chapter has the aim of disclosing the role of selenide or hydrogen selenide (Se 2 or HSe ) as central metabolite of selenium and as an important antidote of the electrophilic mercury forms (particularly, Hg 2+ and MeHg)