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Methods/Design The systematic review protocol follows the recommendations of the Preferred Reporting Items for Systematic Review and Meta-analysis Protocol (PRISMA-P) [16], and to ensure the quality of the protocol, the PRISMA-P checklist was completed (S1 Checklist)

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Protein: Maintain adequate protein intake (and overall micronutrient sufficiency) to support collagen-building pathways

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Mechanism of the reaction of ebselen with endogenous thiols: Dihydrolipoate is a better cofactor than glutathione in the peroxidase activity of ebselen