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Molecular origin of cancer: Catechol estrogen-3,4-quinones as endogenous tumor initiators

Monoamines are highly unstable, chemically reactive molecules , any unbound cytoplasmic neurotransmitter is highly prone to auto-oxidation in the cytosol (Lohr et al., 2014

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For example, in testicular germ cell tumors, in which TP53 is predominantly wild type, the patients experience better cure rates to a cisplatin-based regimen than most other adult solid tumor patients [38]

The PI3K-Akt signaling pathway can transmit extracellular stimuli through the cell membrane to the cytoplasm, and plays an important role in testicular development and spermatogenesis 50

Chk1 is activated by the signal received in response to DNA damage