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Adjuvant immunotherapy by Interferon (IFN)- is the treatment of melanoma which has shown a significant improvement of disease-free survival, and also impact on overall survival, albeit with significant toxicity

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In addition, pathological tau has been shown to spread between neurons through seeded, prion-like propagation, in which misfolded tau can induce templated aggregation in connected cells, thereby contributing to the progression of tau pathology across brain regions