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In addition, NFPS displays slow dissociation kinetics, consistent with a pseudo-irreversible mode of interaction with the transporter and is therefore considered a highly potent and selective GlyT1 inhibitor

10.1097/phm.0000000000001345 80 YonemitsuR.TokunagaT.ShukunamiC.IdeoK.ArimuraH.KarasugiT.et al (2019)

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Springer Singapore, Singapore, pp 71100

Whether or not activation of an NMDA receptor induces long-term depression or potentiation may rest on the frequency of synaptic inputs, and consequently how much Ca2+ enters through the NMDA receptor channel