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Additionally, IGF-2 can also act over IGF-1R, IR and hybrid receptors but with reduced affinity [103]

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Dinkova-Kostova AT, Liby KT, Stephenson KK, Holtzclaw WD, Gao X, Suh N, et al

Research trials soon confirmed that a few months of GH replacement therapy could improve nearly all of these parameters in GHD patients