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The level of reactive species in the cellular system may be reduced by antioxidants either by restricting the expression or activities of free radical-producing enzymes such as xanthine oxidase (XO) and NAD(P)H oxidase, or by enhancing the expression and activities of antioxidant enzymes such as glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) (Shahidi and Zhong, 2015

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Several clinical trials of phytochemicals including curcumin, EGCG, resveratrol, apigenin and berberine for the treatment of various autoimmune diseases have been recently completed or are still ongoing that indicates the potential clinical benefits of these compounds ( Table 3 .)