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Abstract To develop an LCMS/MS method for simultaneous quantification of mildronate and L-carnitine, and to investigate the pharmacokinetic profile of mildronate in rats, its effect on L-carnitine homeostasis, as well as the exposure characteristics, underlying mechanisms, and their associations with therapeutic efficacy and toxicity risks

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The clinical and biochemical outcomes for both groups, before and after the 12-week intervention, are demonstrated in Table 2

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Indirect evidence for autonomic dysfunction

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