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In the absence of SPRTN, these persistent DPCs lead to DNA damage and mutagenesis, likely contributing to the development of hepatocellular carcinoma in patients with Ruijis-Aalfs syndrome

Karagulle 2007)

Research suggests that disturbances in iron homeostasis might initiate considerable oxidative stress and inflammatory reactions, resulting in neuronal damage and exacerbating the progression of AD [62, 63]