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Clinical studies have shown that at the time of diagnosis, -cell mass and function are significantly reduced in patients with T2DM [27]

The function of GPX4 depends on the availability of GSH, whose synthesis and regeneration are under Nrf2 control

& Geha, R

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The authors declare that they have no conflicts and were not involved in the journal's review or decision regarding this manuscript

However, it is not known whether the changes in TNF concentrations in vitro are clinically relevant [29]