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In FD, when patients attempt voluntary movement to command in a direction opposite that of the dystonic posturing, this may activate antagonist muscles but with limited (and in some cases apparently no) activity in the agonist muscles, which is very unusual, as co-contraction of antagonistic muscles is a hallmark of OD (61)

Interestingly, the subcellular localization of NRN1 is dynamic and can be influenced by the neurochemical environment

Radiotherapy toxicity

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Pharmaceutical peptides undergo extensive clinical testing before approval

10.1111/jpi.12718 13 Cardoso-JaimeV.BroderickN