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Cell Metab (2021) 33:19882003.e7

Results: The random forest model showed the bestperformance (AUC = 0.74, 95% CI: 0.6770.801

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In aggregate, whilst it may be premature to speculate, given safety, tolerability and cost effectiveness remain to be confirmed, siRNA inhibition of ANGPTL3 may offer a futuristic panacea for targeting HTG in a wide range of dyslipidaemic settings, including residual elevation in LDL cholesterol in FH [92]