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Genetic variants in antioxidant enzymes and mitochondrial function genes may influence individual glutathione levels and oxidative stress susceptibility

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1, 2 IGF-1R is primarily activated by its high-affinity ligands, IGF-1 and IGF-2, though it can also bind insulin with lower affinity

Through the Cori cycle, the lactate produced in excess by aerobic glycolysis is converted into glucose and, as a result, there is a gain of energy by the cancer and a net loss of energy by the host (142)

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PMID: 14711815