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3D reconstruction of a liver from an APAP-overdosed wild-type mouse undergoing confocal intravital microscopy

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Parra-Bonilla G, Alvarez DF, Al-Mehdi AB, Alexeyev M, Stevens T (2010) Critical role for lactate dehydrogenase A in aerobic glycolysis that sustains pulmonary microvascular endothelial cell proliferation

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When glutathione is depleted, these detoxification pathways become impaired, leading to toxic buildup that can worsen liver damage