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Description

Mutations in sarcomeres in hypertrophic cardiomyopathy (HCM) lead to cardiac fibrosis, which affects contractility (71)

The goal should be evidence, oversight, and access in that order, without sacrificing any of the three

10.1038/nature10337 9 DescheneE

Locus has begun dosing participants in the phase II portion of the trial, which focuses on a combination of IV and urethral delivery of the CRISPR-based treatment plus oral antibiotics