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Indeed, rapamycin, an inhibitor of mTOR, suppressed the amino acid-induced upregulation of p-STAT3-S727 and decreased VGF levels (Fig

TSG-6, Tumor necrosis factor alpha stimulated gene-6

The primary structural proteins of caveolae, known as caveolins, have a strong affinity for cholesterol and play key roles in several metabolic processes, including glucose homeostasis, bile acid signaling, lipid transport, ketogenesis, and mitochondrial respiration

For the hypoxic experiments, medium was incubated in the hypoxic chamber for 48 h before use for the treatment of 1919 and 2012.2 cells

None of the samples had a cytochrome c test exceeding 10%, suggesting mitochondrial inner membrane integrity