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P2Y1R inhibition significantly alleviated KA toxicity in hippocampal neurons, thus indirectly exerting a neuroprotective effect [66]

Hormones 17-estradiol (E2) at high concentrations reached during pregnancy, increases CYP2B6 expression [38]

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Furthermore, the development of hemolytic anemia in Prx2 knock-out mice [72, 73, 74] and the high turnover rate of Prx2 with H 2 O 2 [5, 75] strengthened the importance of the role of Prx2 in RBC antioxidant protection

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