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70 , 232 , 233 Fibroblasts in the murine splenic red pulp appeared to serve a similar function as they also expressed both Csf1 and Il34

doi: 10.1093/neuros/nyaa473 93

doi: 10.3168/jds.2020-19222

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Ultimately, this leads to inhibition of 5-FU induced apoptosis and treatment resistance, which was demonstrated in vitro and in vivo (109)

HFD inhibits the transcription of key antioxidant genes by triggering NRF2 translocation into obese mouse Tregs nucleus, causing a rapid decline in HO-1 expression in Tregs, leading to enhanced oxidative stress and possible ferroptosis, and causing an intensification of obesity and inflammatory responses (156) ( Figure 3 )