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Recent Advances in Cocoa Flavanols on Signaling Pathways In the last two decades, an emerging topic has been the study of the effect of flavonoids on MAPK and upstream/downstream-related proteins, receptors, or enzymes that control the cellular processes, such as proliferation, differentiation, apoptosis, and stress responses, under both normal and pathological conditions

Hepatology 59 , 10941106 (2014)

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Additionally, research has shown that 1 O 2 oxidizes mitochondrial ETC proteins, which results in defective mitochondrial respiration [49]