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In these diseases, ferroptosis contributes to cell membrane disruption, induce oxidative stress, and mitochondrial function, ultimately leading to cell damage and organ dysfunction 19,20

Inactivation of GPX4 can occur through two processes: depletion of intracellular glutathione (GSH) or direct targeting of GPX4

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These important pro-inflammatory biomarker factors, such as 9-HODE and 13-HODE, were elevated in DM in our study