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This model successfully predicted a moderate clinical HDI risks (1.57-fold) between SJW and anticancer drugs such as acalabrutinib, osimertinib, and olaparib [139]

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Inflammation can damage lung tissue and induce DNA damage in lung cells, mitochondrial DNA damage leads to the dysregulation of mitochondrial quality control, which lays the foundation for the malignant transformation from stage II (such as pulmonary fibrosis) to stage III (lung cancer), thereby increasing the risk of lung cancer (Taucher et al., 2022)