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Methods Data from the Merative MarketScan Research Databases (20072021) were used to identify adult patients using ICD-9/10 codes

Crit Rev Food Sci Nutr 60(18):31553171

With respect to Trp216 in DAP BII, the tryptophan residue is conserved in 537 sequences (81.24%), while conservative substitutions are observed in the rest of 124 sequences [replaced by phenylalanine in 94 sequences (14.22%) and tyrosine in 30 sequences (4.54%)]

Gastric acid and proteolytic enzymes degrade most peptide bonds before absorption

what it doesn't tolerate is multi-day gaps that drop plasma levels below therapeutic threshold before the next dose