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When treated with 5FU, cancer cells specifically increase mitochondrial content to buffer nucleotide stress, whereas stromal cells do not, meaning that cancer cells become intrinsically more dependent on mitochondrial metabolism

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Dilda, Tumour Metabolism Group, Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia e-mail: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology