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Elevations in blood pressure (180 mmHg systolic or 110 mmHg diastolic) were observed in approximately 18% of healthy subjects (not exposed to cyanide) receiving hydroxocobalamin 5 g and 28% of subjects receiving 10 g

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Drinking at High Altitude Scientific explanation: Higher altitudes increase fluid loss through faster breathing rates and increased urination (a response called altitude diuresis), which independently reduces total body water again stacking with alcohols own diuretic effect