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Blue light, the high-energy short-wave light, can penetrate the cornea and lens, reaching the retina and ultimately inducing photochemical damage 16,20

To enhance the practical applicability of this framework, future research should also address the heterogeneity in dosing, treatment duration, and patient phenotypes observed across existing studies

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Importantly, the continuous elevation of endogenous O 2 levels by CAT suppressed the expression of HIF-1 in both normoxia (21% O 2 ) and hypoxia conditions (1% O 2 , Fig