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This peptide has demonstrated protective effects in preclinical models of heart failure, neurodegenerative disease, and agerelated muscle atrophy, and received FDA accelerated approval in 2025 as the first treatment for Barth syndrome [3]

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FOXO4-DRI is studied within the senolytic compound class alongside navitoclax and quercetin analogs, with researchers using it as a peptide-based mechanistic comparator targeting the FOXO4-p53 axis specifically

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