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In Chinese Hamster Ovary (CHO) cells, luteolin reduced reactive oxygen species (ROS) accumulation, prevented mitochondrial depolarization, and suppressed apoptosis ( 4.2 Primary ovarian insufficiency Primary ovarian insufficiency (POI), historically referred to as premature ovarian failure (POF), affects 1%3% of women under 40 and arises from accelerated follicular loss or dysfunction (Touraine et al., 2024)