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A new thiol-independent mechanism of epithelial host defense against Pseudomonas aeruginosa : iNOS/NO() sabotage of theft-ferroptosis

In terms of the mitochondrial homeostasis modulated by the AMPK pathway, in addition to the NAD + /SIRT1/PGC-1/FOXO axis-induced mitigation of mitochondrial oxidative stress via ROS scavenging and mitophagy, 98 AMPK-mediated induction of p53 signaling, AMPK-mediated inhibition of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B), mTORC1, and HIF-1 signaling are directly or indirectly associated with mitochondrial health protection

Primer sequences for qPCR are listed in support data (S17)

This is the actual decision process Valeria Marulanda follows in our Doral clinic

Based on these hypothesized mechanisms, several potential intervention strategies can be considered

10.1002/bio.70005 177 SatiA.RanadeT