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R 1 is as defined above and X is a leaving group, for example and not restricted to, the tosyl group, the mesyl group and halogen groups among others

This was also the case of the referral from Macau who was a 10-year-old proband with dilated cardiomyopathy.6 Founder Mutation R254X In 2002, we reported for the first time a common mutation, R254X which was found in referral cases from Macau, Taipei, and Kaohsiung.6 R254X is a mutation changing the codon 254 from Arginine to a stop codon which causes a loss of function of the transporter

Cardiovascular Imaging Case Rpts

These aren't edge cases