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Curiously, CT2 that, in normal conditions, has a very narrow and specific tissue distribution, becomes widely expressed in cancers even originating from tissues in which CT2 is normally not present, further highlighting the carnitine role in human cancers

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As a proof of concept to show the adjuvant effects of histidine during ICI in 60% of patients with advanced cancer presenting a gut dysbiosis at baseline, histidine injection by an intravenous route (to bypass gut dysbiosis) may be a reasonable option

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Let's explore carnitine types and find out what makes each one special: D-carnitine : Ironically, this inactive form might cause a carnitine deficiency by blocking the absorption of other beneficial forms

Consequently, the patient ID was the only covariate used to account for variability between patients