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25,26 The behavior and therapeutic potential of MSCs are tightly regulated by intrinsic and extrinsic factors, including microenvironmental cues, epigenetic modifications, and cytokine signaling, where MSCs release a diverse range of bioactive molecules, including growth factors, cytokines, and extracellular vesicles (EVs)

Clarifying regulatory mechanisms and targeting biomarkers of CSCs is currently the mainstream idea

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Conversely, histone deacetylases (HDACs) remove acetyl groups, leading to chromatin condensation and gene repression