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Disease-associated mutations affect TIA1 phase separation and aggregation in a proline-dependent manner

The results indicated that some of these genes were specifically enriched by Pc in C929-Gal4 (l-LNvs cluster) and R6-Gal4 marked (s-LNvs cluster) neurons (e.g., per , Rh5 , Mid1 , nvy , kay , B4 , and Bx )

The raw data and complete analysis script are available on GitHub

Importantly, Ca 2+ - and ROS-dependent LMP has been reported to contribute to necroptosis via release of cathepsins, cathepsins-mediated mitochondrial dysfunction, and lysosome-dependent regulation of RIPK1 and RIPK3 post-translational modifications [141]

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