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This upregulation leads to an increased expression of lipogenic genes, including sterol regulatory element-binding proteins (SREBP1c) and diacylglycerol acyltransferase-2 (DGAT2), which suggests that miR-370 provides a further point of regulation of this pathway 86

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2009 Feb;41(1):9-14

Irrespective of the stressors that activate the ISR, its activation leads to the phosphorylation of the -subunit of eukaryotic translation initiation factor 2 (eIF2) at serine 51, resulting in attenuation of cap-dependent protein translation

doi: 10.3389/fendo.2023.1183060

This initiates the buildup of reactive oxygen species (ROS) and lipid peroxides, leading to the demise of cancer cells