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RNA-Seq analysis provided direct evidence that LSC-Exo not only were able to efficiently reduce immune activation, maintain intracellular ROS homeostasis, and dampen inflammatory cytokine storm, but also alleviated pulmonary dysfunction in the hamsters by activating the antioxidant defense systems

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APE1 also negatively regulates nuclear factor erythroid-related factor 2 (NRF2), a prominent antioxidant that is protective against oxidative damage triggered by injury and inflammation (Fishel et al., 2015)