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Targeted combination therapies GBM treatment resistance often arises from extensive intra- and intertumoral heterogeneity, necessitating combination therapies targeting multiple pathways

Which Ill explain now

Toll-like receptor-7 ligand Imiquimod induces type I interferon and antimicrobial peptides to ameliorate dextran sodium sulfate-induced acute colitis

however, they can be rapidly contaminated with bacteria [123,124,125]

On the other hand, non-genetic risk factors as metabolic disorders (i.e., obesity, diabetes mellitus, non-alcoholic fatty liver disease, etc.), were highly connected with gallstone formation 7,8,9