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Defects in the AR gene can be caused by four types of mutations: (i) Single point mutations resulting in substitutions or premature stop codons, (ii) nucleotide insertions and deletions resulting in frameshifts, (iii) complete or partial deletion of the gene, or (iv) intronic mutations that affect AR RNA splicing 103

& Elinav, E

Int J Mol Sci (2020) 21:6451

The rate of telomere sequence loss in human leukocytes varies with age

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The gut flora is considered to be a large secretory organ, which produces trimethylamine-N-oxide (TMAO), short-chain fatty acids and secondary bile acids by breaking down the ingested food