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Likewise, physical contact with stromal cells (e.g., fibroblasts) or paracrine signaling can induce epigenetic changes in cancer cells, resulting in notably distinct epigenetic profiles across various tumor regions [208,209,210]

An example of this kind of effect can be found in the long-term responses to other forms of environmental or social stressors, particularly experienced early in life, which become potent epigenetic stimuli for increased susceptibility to later obesity and heart disease 8,18,19

Consequently, we measured the concentration of acetate and found that it was accumulated

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In this context, the deployment of landscape quality indicators emerges as a cornerstone of effective decision-making within Environmental Assessment procedures (Shames & Scherr, 2019

Targeting immunogenic cell death in cancer