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226-228 A trial in which 36 subjects with fibromyalgia received placebo and increasing doses of melatonin (3 mg, 6 mg, 9 mg, 12 mg, and 15 mg nightly) during alternating 10-day cycles found 9 mg, 12 mg, and 15 mg of melatonin per day decreased scores on the Fibromyalgia Impact Questionnaire, number of tender points, and urinary cortisol levels

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Generally, we use peptides in 3 to 6-month intervals, and your blend changes or stops after those intervals depending on the goal for treatment

However, no studies have shown benefit for one PDE-5 inhibitor over another