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The clinical success of iron chelation in this context validated the principle of targeting toxic iron overload

In the future, considerable effort will be needed to characterize the interactions of these epigenetic marks with metabolic reprogramming factors in cancer cells

Centro De Investigacin Biomdico En Red Enfermedades Hepticas y Digestivas (CIBERehd), Madrid, Spain., (3)Universidad De Mlaga, Mlaga, Spain, (4)Clnicas Hospital, Montevideo, Uruguay, (5)Centenario Hospital, Rosario National University, Rosario, Argentina Background : Positive drug-induced liver injury (DILI) rechallenge has been traditionally related to higher severity

The resulting acetoxyarylamines are highly unstable, spontaneously forming arylnitrenium ions that bind to DNA (Bland & Kadlubar, 1985) and ultimately lead to mutagenesis and carcinogenesis (Kerdar et al., 1993)