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Treating RPE cells with the iron chelator deferoxamine (DFO) can lead to a reduction in intracellular iron ions (154), an increase in genes related to iron transport, a significant elevation in the level of hypoxia-inducible factor HIF2, and impairment of mitochondrial function, indicating that the RPE is the main target tissue for DFO toxicity, resulting in atrophy and degeneration of the RPE and posing a risk of retinal detachment

If melanocyte stem cells cannot self-renew or differentiate, then fewer melanocytes are made, less melanin is produced, and our hair loses its pigment and turns grey

Dapagliflozin Acutely Improves Endothelial Dysfunction, Reduces Aortic Stiffness and Renal Resistive Index in Type 2 Diabetic Patients: A Pilot Study

In the replication cohort, IVW analysis confirmed similar protective effects (OR = 0.96

Almasi A, Shahhosseini S, Haeri A, Daha FJ, Geramifar P, Dadashzadeh S

Therefore, a dose of 100 g/mL was selected as the maximum dose to evaluate the effects of CME on LPS-induced inflammatory cytokine production in IPEC-J2 cells